| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
CCR5D32 mutation in three Brazilian populations of predominantly Sub-Saharan African ancestry
|
| Autores: |
Carvalho,Mônica W.P.
Leboute,Ana P.M.
Oliveira,Silviene F.
Sousa,Sandra M.B.
Klautau-Guimarães,Maria de Nazaré
Simões,Aguinaldo L.
|
| Data: |
2004-01-01
|
| Ano: |
2004
|
| Palavras-chave: |
CCR5
Genetic polymorphism
Sub-Saharan Afro-derived Brazilian populations
Ethnic-grouspecific marker
|
| Resumo: |
This study reports the frequencies of the CCR5D32 mutation of the beta-chemokine 5 gene and discusses the possible effects of past and recent gene flow in three quilombo remnants (Brazilians communities with anthropological African ancestry whose ancestors were escaped slaves): Rio das Rãs, Mocambo, and São Gonçalo in the northeastern region of Brazil. The CCR5D32 allele frequency of the Mocambo population was significantly higher (5.6%) than that found in the Rio das Rãs (1%) and São Gonçalo (0.9%) populations. These differences may reflect different proportions of parental populations in the founders individuals, a founder-effect and/or different histories of inter-ethnic contact. The frequency of the CCR5D32 allele in the Mocambo sample is similar to that found in those urban Brazilian populations which have a large amount of European genetic input, indicating a European contribution to the gene pool of this population and suggesting that, perhaps since its foundation, Mocambo has had a high level of admixture or experienced a founder-effect.
|
| Tipo: |
Info:eu-repo/semantics/article
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300002
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-47572004000300002
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.27 n.3 2004
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
